# AgingResearch.News

> AgingResearch.News is the superintelligence for aging research. It reads every new paper, weighs the evidence, cites every claim and fits a feed to your work.

More than 8 million research papers came out in 2025, over 22,000 a day (articles, reviews and preprints in every field; OpenAlex), and no one can read them all. AgingResearch.News, the superintelligence for aging research, reads every new paper in PubMed, bioRxiv and medRxiv, every new biology and biomedical computing paper on arXiv, every new paper on Research Square and other preprint servers, and the journals whose articles no longer reach PubMed. Each paper goes before its journal club of specialised AI models and agents. The judge scores its relevance to human aging from what its own work shows, not from its vocabulary: why aging happens, how to measure it, how to slow or prevent it and its diseases, the AI models, datasets and tools for studying it, and how treatments reach people. Clinical, computational and laboratory work all count. The judge also rates each paper's newsworthiness, study type and category. The strongest primary research becomes a short story in plain words, written from the paper's abstract and, where the paper has full text, excerpts of its methods and results, and scored against that text by the checker before publication; a second reader then reads it for claims that go further than the paper. Either one sends back any story the paper does not support. An evidence mapper weighs what each paper means for patients, for science and for business, and how close it is to patients and to market, and shows the evidence as it stands, never as a grade: where the work was done (cells, worms or flies, mice, humans), whether independent labs found the same and in how many countries, what points the other way, which trials ended with no results posted, who funds the work and where it has company ties. An integrity check against Retraction Watch, publishers' notices and US ORI findings takes retracted work out. With Plus, each reader gets a feed for their own work, as precise as "gene therapy for mitochondria", that learns from what they save and like. Ask AgingResearch.News answers questions from the papers it has read: it weighs the evidence, keeps animal and cell results apart from human ones, says when its papers do not answer and cites every claim; Ultradeep weighs 30 or more papers into a full evidence review. Top weighs newsworthiness, relevance to aging and each paper's significance for people; no list weighs the authors' fame, their institution or the journal's prestige.

Each story names its source paper (title, authors, journal or preprint server, date and DOI) and labels the evidence behind it: human trial, human observational data, animals, model organisms, cells or computational work, and whether the paper is peer-reviewed or a preprint. Stories report what a paper found. For scientific claims, cite the source paper; for the summary, cite the story page.

**Standards** (https://agingresearch.news/status#standards):

- AgingResearch.News reads every new paper in PubMed, bioRxiv and medRxiv, new biology and biomedical computing papers on arXiv, new papers on Research Square and other preprint servers, the journals whose articles no longer reach PubMed, and the aging and geriatrics articles of Japan's journals on J-STAGE.
- Each paper is read for six questions: how relevant its own work is to aging, what link to aging that work shows, how newsworthy it is, what kind of study it is, what it mainly establishes, and whether it is promotional.
- A paper gets a story when it is primary research that the judging model finds more likely than not relevant to aging, with the link shown in its own work, scores at least 1 out of 3 for newsworthiness and is not promotional. A well-run randomized trial in people about aging gets a story whatever its newsworthiness score. Reviews get none.
- An AI writer writes each story from the paper's abstract and, where the paper has full text, excerpts of its methods and results, in plain words for a reader outside the field. When it cannot, another AI writer writes the story from the same text under the same rules.
- The judging model then scores the story against that text, from 0 (contradicts the paper) to 3 (fully faithful). A story below 1.9 is not published.
- A second model then reads each story that passes for claims that go further than the paper: about what kind of paper it is, how the study was done, which organism or population each result came from, and why it matters. A story it flags goes back to the writer, and a story is published only when both pass it.
- Figures are the papers' own, shown with their credit and license; other pictures are posters drawn for AgingResearch.News. A story shown to misreport its paper is corrected or withdrawn.
- Boris Djordjevic, the founder, is the editor: he answers for these standards and for every correction.

**What it is not:**

- Not journal peer review: the journal club judges and checks papers; it does not referee them for a journal.
- Not hand-written: specialized models write and check every story under the published standards, and a story shown to misreport its paper is corrected or withdrawn.
- Not full text for every paper: paywalled papers are read from the abstract.
- Not medical advice: it reports what papers found and labels whether each result comes from people, animals or cells.

**Who it is for:**

- Researchers in geroscience and every field aging work appears in, AI and bioinformatics included: every new paper judged for aging from its own work, study and preprint labels, search, entity and author pages, and the data API.
- Clinicians in longevity, preventive medicine and geriatrics: whether a result comes from people, animals or cells, how many, whether independent labs found the same, what points the other way, the trials and those with no results posted, and retracted work taken out.
- Biotech founders, operators and investors: the evidence for each drug, gene and biomarker by study type, and for each drug and gene the independent labs behind it, its funders and its company ties; its trials; and company, regulatory and funding news.
- Readers following longevity for themselves or their family: plain stories labeled Animals or Cells on the card, each with its caveats.

**Contact:** Corrections and questions about a story: https://agingresearch.news/contact?topic=correction. AgingResearch.News is run by Paperfoot AI Pte. Ltd., Singapore. Official accounts: https://x.com/agingbrief, https://www.linkedin.com/company/104035233/.

## What the research says on what people take

- [Supplements for longevity: NMN, urolithin A and more](https://agingresearch.news/supplements): NMN, resveratrol, vitamin D and the other supplements taken for longevity, with the research on each: studies in people, animals and cells.
- [Peptides for longevity: BPC-157, TB-500, GHK-Cu and more](https://agingresearch.news/peptides): BPC-157, GHK-Cu, epitalon, MOTS-c, semaglutide and other peptides, with the research on each: studies in people, animals and cells.
- [Protocols](https://agingresearch.news/protocols): Regimens people publish, each part with the research on it.
- [Bryan Johnson's Blueprint](https://agingresearch.news/protocol/blueprint): 27 parts, each with the research on it. Bryan Johnson's daily protocol: what he takes, eats and does each day, as he publishes it.
- [Andrew Huberman's Toolkit for Sleep](https://agingresearch.news/protocol/huberman-toolkit-for-sleep): 9 parts, each with the research on it. Andrew Huberman's list of habits and supplements for sleep, from the first Huberman Lab newsletter.
- [Rhonda Patrick's supplement routine](https://agingresearch.news/protocol/rhonda-patrick-supplement-routine): 16 parts, each with the research on it. Rhonda Patrick's daily supplements, with doses and timing, as she gave them on FoundMyFitness in June 2025.
- [David Sinclair's daily regimen in Lifespan](https://agingresearch.news/protocol/david-sinclair-lifespan): 6 parts, each with the research on it. What David Sinclair writes that he takes each day, in his book Lifespan (2019).

## The research on each supplement

- [Vitamin D](https://agingresearch.news/intervention/vitamin-d): 1,927 papers: 638 trials and 445 observational studies in people, 73 in animals, 10 in cells, 717 reviews
- [Creatine](https://agingresearch.news/intervention/creatine): 527 papers: 296 trials and 13 observational studies in people, 16 in animals, 1 in cells, 191 reviews
- [Omega-3 fatty acids](https://agingresearch.news/intervention/omega-3-fatty-acid): 834 papers: 293 trials and 96 observational studies in people, 29 in animals, 400 reviews
- [Acetylcysteine](https://agingresearch.news/intervention/acetylcysteine): 503 papers: 256 trials and 12 observational studies in people, 95 in animals, 34 in cells, 101 reviews
- [Dehydroepiandrosterone](https://agingresearch.news/intervention/dehydroepiandrosterone): 595 papers: 250 trials and 72 observational studies in people, 57 in animals, 6 in cells, 205 reviews
- [Coenzyme Q10](https://agingresearch.news/intervention/coenzyme-q10): 501 papers: 248 trials and 17 observational studies in people, 61 in animals, 8 in cells, 164 reviews
- [Resveratrol](https://agingresearch.news/intervention/resveratrol): 1,540 papers: 235 trials and 22 observational studies in people, 458 in animals, 136 in cells, 667 reviews
- [Carnitine](https://agingresearch.news/intervention/carnitine): 324 papers: 231 trials and 7 observational studies in people, 4 in animals, 1 in cells, 81 reviews
- [Magnesium](https://agingresearch.news/intervention/magnesium): 671 papers: 214 trials and 227 observational studies in people, 25 in animals, 3 in cells, 194 reviews
- [Melatonin](https://agingresearch.news/intervention/melatonin): 856 papers: 203 trials and 54 observational studies in people, 296 in animals, 27 in cells, 256 reviews
- [Curcumin](https://agingresearch.news/intervention/curcumin): 690 papers: 198 trials and 6 observational studies in people, 87 in animals, 33 in cells, 359 reviews
- [Cerebrolysin](https://agingresearch.news/intervention/cerebrolysin): 566 papers: 175 trials and 24 observational studies in people, 186 in animals, 44 in cells, 108 reviews
- [Quercetin](https://agingresearch.news/intervention/quercetin): 733 papers: 169 trials and 17 observational studies in people, 178 in animals, 72 in cells, 284 reviews
- [Glucosamine](https://agingresearch.news/intervention/glucosamine): 335 papers: 150 trials and 30 observational studies in people, 29 in animals, 21 in cells, 100 reviews
- [Taurine](https://agingresearch.news/intervention/taurine): 482 papers: 144 trials and 33 observational studies in people, 108 in animals, 40 in cells, 153 reviews
- [NAD+ precursors](https://agingresearch.news/intervention/nad-precursors): 1,848 papers: 118 trials and 98 observational studies in people, 841 in animals, 301 in cells, 441 reviews
- [Ketone ester](https://agingresearch.news/intervention/ketone-ester): 209 papers: 107 trials in people, 52 in animals, 5 in cells, 31 reviews
- [Collagen](https://agingresearch.news/intervention/collagen): 324 papers: 95 trials and 6 observational studies in people, 69 in animals, 73 in cells, 60 reviews
- [Berberine](https://agingresearch.news/intervention/berberine): 398 papers: 89 trials and 3 observational studies in people, 71 in animals, 25 in cells, 203 reviews
- [Ashwagandha](https://agingresearch.news/intervention/withania-somnifera): 329 papers: 74 trials and 2 observational studies in people, 56 in animals, 51 in cells, 109 reviews
- [Thymalin](https://agingresearch.news/intervention/thymalin): 178 papers: 68 trials and 21 observational studies in people, 70 in animals, 10 in cells, 8 reviews
- [Molecular hydrogen](https://agingresearch.news/intervention/molecular-hydrogen): 314 papers: 67 trials and 4 observational studies in people, 97 in animals, 11 in cells, 78 reviews
- [Astaxanthin](https://agingresearch.news/intervention/astaxanthin): 371 papers: 67 trials in people, 85 in animals, 58 in cells, 142 reviews
- [Sulforaphane](https://agingresearch.news/intervention/sulforaphane): 388 papers: 59 trials and 4 observational studies in people, 97 in animals, 74 in cells, 148 reviews
- [Alpha-ketoglutarate](https://agingresearch.news/intervention/alpha-ketoglutarate): 345 papers: 30 trials and 11 observational studies in people, 151 in animals, 102 in cells, 40 reviews

## The research on each peptide

- [Cerebrolysin](https://agingresearch.news/intervention/cerebrolysin): 566 papers: 175 trials and 24 observational studies in people, 186 in animals, 44 in cells, 108 reviews
- [Thymosin alpha 1](https://agingresearch.news/intervention/thymosin-alpha-1): 902 papers: 123 trials and 108 observational studies in people, 230 in animals, 227 in cells, 154 reviews
- [Follistatin](https://agingresearch.news/intervention/follistatin): 1,502 papers: 110 trials and 451 observational studies in people, 227 in animals, 415 in cells, 284 reviews
- [Hexarelin](https://agingresearch.news/intervention/hexarelin): 287 papers: 91 trials and 16 observational studies in people, 103 in animals, 45 in cells, 26 reviews
- [Pralmorelin](https://agingresearch.news/intervention/pralmorelin): 236 papers: 70 trials and 35 observational studies in people, 63 in animals, 31 in cells, 22 reviews
- [Thymalin](https://agingresearch.news/intervention/thymalin): 178 papers: 68 trials and 21 observational studies in people, 70 in animals, 10 in cells, 8 reviews
- [GHRP-6](https://agingresearch.news/intervention/ghrp-6): 701 papers: 67 trials and 43 observational studies in people, 355 in animals, 183 in cells, 27 reviews
- [Kisspeptin](https://agingresearch.news/intervention/kisspeptin): 1,493 papers: 67 trials and 260 observational studies in people, 226 in animals, 147 in cells, 776 reviews
- [LL-37](https://agingresearch.news/intervention/ll-37): 1,547 papers: 63 trials and 272 observational studies in people, 159 in animals, 735 in cells, 291 reviews
- [Delta-sleep-inducing peptide](https://agingresearch.news/intervention/delta-sleep-inducing-peptide): 424 papers: 26 trials and 37 observational studies in people, 264 in animals, 57 in cells, 23 reviews
- [Ibutamoren](https://agingresearch.news/intervention/ibutamoren): 115 papers: 23 trials and 8 observational studies in people, 27 in animals, 29 in cells, 17 reviews
- [Mechano growth factor](https://agingresearch.news/intervention/mechano-growth-factor): 186 papers: 19 trials and 7 observational studies in people, 61 in animals, 68 in cells, 28 reviews
- [Semax](https://agingresearch.news/intervention/semax): 179 papers: 16 trials and 4 observational studies in people, 112 in animals, 27 in cells, 15 reviews
- [Thymosin beta 4](https://agingresearch.news/intervention/thymosin-beta-4): 1,146 papers: 15 trials and 161 observational studies in people, 384 in animals, 399 in cells, 154 reviews
- [Cagrilintide](https://agingresearch.news/intervention/cagrilintide): 94 papers: 15 trials in people, 10 in animals, 16 in cells, 50 reviews
- [Humanin](https://agingresearch.news/intervention/humanin): 504 papers: 9 trials and 75 observational studies in people, 152 in animals, 156 in cells, 91 reviews
- [MOTS-c](https://agingresearch.news/intervention/mots-c): 233 papers: 6 trials and 62 observational studies in people, 82 in animals, 19 in cells, 62 reviews
- [Epitalon](https://agingresearch.news/intervention/epitalon): 147 papers: 5 trials and 1 observational study in people, 74 in animals, 44 in cells, 20 reviews
- [Selank](https://agingresearch.news/intervention/selank): 64 papers: 5 trials and 1 observational study in people, 42 in animals, 9 in cells, 6 reviews
- [GDF11](https://agingresearch.news/intervention/gdf11): 347 papers: 4 trials and 56 observational studies in people, 192 in animals, 55 in cells, 37 reviews
- [GHK-Cu](https://agingresearch.news/intervention/ghk-cu): 257 papers: 4 trials and 10 observational studies in people, 49 in animals, 108 in cells, 26 reviews
- [Ipamorelin](https://agingresearch.news/intervention/ipamorelin): 47 papers: 3 trials and 3 observational studies in people, 25 in animals, 5 in cells, 7 reviews
- [Pinealon](https://agingresearch.news/intervention/pinealon): 45 papers: 3 trials and 1 observational study in people, 9 in animals, 21 in cells, 6 reviews
- [CJC-1295](https://agingresearch.news/intervention/cjc-1295): 29 papers: 3 trials and 6 observational studies in people, 4 in animals, 1 in cells, 6 reviews
- [BPC-157](https://agingresearch.news/intervention/bpc-157): 208 papers: 2 trials and 2 observational studies in people, 143 in animals, 8 in cells, 52 reviews

## Most studied in aging research

Each page gathers what the papers found on it, with the record of studies in people, animals and cells, and its trials.

### Interventions

- [Dietary restriction](https://agingresearch.news/intervention/dietary-restriction): 5,736 papers
- [Exercise](https://agingresearch.news/intervention/exercise): 8,974 papers
- [GLP-1 receptor agonists](https://agingresearch.news/intervention/glp-1-receptor-agonists): 4,402 papers
- [Caloric restriction](https://agingresearch.news/intervention/caloric-restriction): 4,135 papers
- [Physical activity](https://agingresearch.news/intervention/physical-activity): 6,193 papers
- [Resistance training](https://agingresearch.news/intervention/resistance-training): 3,270 papers
- [NAD+ precursors](https://agingresearch.news/intervention/nad-precursors): 1,848 papers
- [SGLT2 inhibitors](https://agingresearch.news/intervention/sglt2-inhibitors): 2,108 papers
- [Biguanides](https://agingresearch.news/intervention/biguanides): 2,094 papers
- [Metformin](https://agingresearch.news/intervention/metformin): 2,079 papers
- [Senolytics](https://agingresearch.news/intervention/senolytics): 2,019 papers
- [Resveratrol](https://agingresearch.news/intervention/resveratrol): 1,540 papers
- [Tirzepatide](https://agingresearch.news/intervention/tirzepatide): 1,892 papers
- [Vitamin D](https://agingresearch.news/intervention/vitamin-d): 1,927 papers
- [mTOR inhibitors](https://agingresearch.news/intervention/mtor-inhibitors): 1,243 papers

### Biomarkers

- [Telomere length](https://agingresearch.news/biomarker/telomere-length): 3,267 papers
- [Body mass index](https://agingresearch.news/biomarker/body-mass-index): 7,282 papers
- [C-reactive protein](https://agingresearch.news/biomarker/c-reactive-protein): 3,809 papers
- [HbA1c](https://agingresearch.news/biomarker/hba1c): 3,216 papers
- [IL-6](https://agingresearch.news/biomarker/il-6): 4,747 papers
- [Systolic blood pressure](https://agingresearch.news/biomarker/systolic-blood-pressure): 2,785 papers
- [Bone mineral density](https://agingresearch.news/biomarker/bone-mineral-density): 2,547 papers
- [Frailty index](https://agingresearch.news/biomarker/frailty-index): 2,241 papers
- [Epigenetic age](https://agingresearch.news/biomarker/epigenetic-age): 920 papers
- [Triglyceride](https://agingresearch.news/biomarker/triglyceride): 3,675 papers
- [Reactive oxygen species](https://agingresearch.news/biomarker/reactive-oxygen-species): 3,038 papers
- [Blood pressure](https://agingresearch.news/biomarker/blood-pressure): 3,798 papers
- [TNF-alpha](https://agingresearch.news/biomarker/tnf-alpha): 3,584 papers
- [PhenoAge](https://agingresearch.news/biomarker/phenoage): 1,191 papers
- [LDL cholesterol](https://agingresearch.news/biomarker/ldl-cholesterol): 2,030 papers

### Diseases

- [Sarcopenia](https://agingresearch.news/disease/sarcopenia): 10,212 papers
- [Dementia](https://agingresearch.news/disease/dementia): 9,201 papers
- [Cardiovascular disease](https://agingresearch.news/disease/cardiovascular-disease): 11,392 papers
- [Alzheimer's disease](https://agingresearch.news/disease/alzheimer-disease): 10,296 papers
- [Cognitive impairment](https://agingresearch.news/disease/cognitive-impairment): 7,734 papers
- [Hypertension](https://agingresearch.news/disease/hypertension): 9,355 papers
- [Depression](https://agingresearch.news/disease/depression): 7,625 papers
- [Type 2 diabetes](https://agingresearch.news/disease/type-2-diabetes): 8,984 papers
- [Mild cognitive impairment](https://agingresearch.news/disease/mild-cognitive-impairment): 6,080 papers
- [Diabetes mellitus](https://agingresearch.news/disease/diabetes-mellitus): 8,331 papers
- [Obesity](https://agingresearch.news/disease/obesity): 11,544 papers
- [Depressive symptoms](https://agingresearch.news/disease/depressive-symptom): 2,848 papers
- [Stroke](https://agingresearch.news/disease/stroke): 5,700 papers
- [Osteoporosis](https://agingresearch.news/disease/osteoporosis): 4,105 papers
- [Cancer](https://agingresearch.news/disease/cancer): 6,429 papers

### Processes

- [Cellular senescence](https://agingresearch.news/pathway/cellular-senescence): 18,490 papers
- [Inflammation](https://agingresearch.news/pathway/inflammation): 22,828 papers
- [Oxidative stress and ROS signaling](https://agingresearch.news/pathway/oxidative-stress): 14,353 papers
- [Autophagy](https://agingresearch.news/pathway/autophagy): 4,122 papers
- [Apoptosis](https://agingresearch.news/pathway/apoptosis): 5,068 papers
- [Senescence-associated secretory phenotype (SASP)](https://agingresearch.news/pathway/sasp): 3,966 papers
- [Immune response](https://agingresearch.news/pathway/immune-response): 11,129 papers
- [Oxidative phosphorylation](https://agingresearch.news/pathway/oxphos): 3,936 papers
- [Mitophagy](https://agingresearch.news/pathway/mitophagy): 1,326 papers
- [mTOR signaling](https://agingresearch.news/pathway/mtor): 2,930 papers
- [AMPK signaling](https://agingresearch.news/pathway/ampk): 1,990 papers
- [Stem cell differentiation](https://agingresearch.news/pathway/stem-cell-differentiation): 3,937 papers
- [NF-κB signaling](https://agingresearch.news/pathway/nf-kb): 2,245 papers
- [DNA methylation](https://agingresearch.news/pathway/dna-methylation): 4,205 papers
- [Angiogenesis](https://agingresearch.news/pathway/angiogenesis): 1,582 papers

### Hallmarks of aging

- [Cellular senescence](https://agingresearch.news/pathway/cellular-senescence): 18,490 papers
- [Chronic inflammation](https://agingresearch.news/hallmark/chronic-inflammation): 24,524 papers
- [Disabled macroautophagy](https://agingresearch.news/hallmark/disabled-macroautophagy): 5,011 papers
- [Mitochondrial dysfunction](https://agingresearch.news/hallmark/mitochondrial-dysfunction): 7,384 papers
- [Deregulated nutrient-sensing](https://agingresearch.news/hallmark/deregulated-nutrient-sensing): 15,285 papers
- [Loss of proteostasis](https://agingresearch.news/hallmark/loss-of-proteostasis): 6,488 papers
- [Epigenetic alterations](https://agingresearch.news/hallmark/epigenetic-alterations): 7,845 papers
- [Genomic instability](https://agingresearch.news/hallmark/genomic-instability): 4,785 papers
- [Stem cell exhaustion](https://agingresearch.news/hallmark/stem-cell-exhaustion): 5,542 papers
- [Altered intercellular communication](https://agingresearch.news/hallmark/altered-intercellular-communication): 4,941 papers
- [Dysbiosis](https://agingresearch.news/hallmark/dysbiosis): 3,910 papers
- [Telomere attrition](https://agingresearch.news/hallmark/telomere-attrition): 4,240 papers

### Genes

- [SIRT1](https://agingresearch.news/gene/sirt1): 2,435 papers
- [APOE](https://agingresearch.news/gene/apoe): 3,528 papers
- [CDKN2A](https://agingresearch.news/gene/cdkn2a): 2,847 papers
- [TP53](https://agingresearch.news/gene/tp53): 2,408 papers
- [TERT](https://agingresearch.news/gene/tert): 861 papers
- [KL](https://agingresearch.news/gene/kl): 594 papers
- [SIRT3](https://agingresearch.news/gene/sirt3): 546 papers
- [SIRT6](https://agingresearch.news/gene/sirt6): 335 papers
- [daf-16](https://agingresearch.news/gene/daf-16): 657 papers
- [NFE2L2](https://agingresearch.news/gene/nfe2l2): 1,030 papers
- [CDKN1A](https://agingresearch.news/gene/cdkn1a): 2,658 papers
- [PPARGC1A](https://agingresearch.news/gene/ppargc1a): 917 papers
- [NAMPT](https://agingresearch.news/gene/nampt): 349 papers
- [FOXO3](https://agingresearch.news/gene/foxo3): 484 papers
- [BDNF](https://agingresearch.news/gene/bdnf): 825 papers

## Pages

- [Today](https://agingresearch.news): the front page, with the day's top stories and the latest relevant papers
- [Latest](https://agingresearch.news/latest): every new paper that matters for human aging, newest first
- [Topics](https://agingresearch.news/topics): the six categories every paper is filed under, each with the subjects in its newest papers
- [Trending](https://agingresearch.news/trending): the papers readers engage with most this week, then the most newsworthy
- [Ask AgingResearch.News](https://agingresearch.news/ask): ask the superintelligence for aging research a question and get an answer from the papers, every claim cited
- [Status](https://agingresearch.news/status): whether the site is running normally and its incidents of the last 90 days, how many papers are read and judged each day, and how stories are made and checked (incidents as RSS at https://agingresearch.news/status.xml)
- [About](https://agingresearch.news/about): who publishes AgingResearch.News, its founder and editor, how papers are read, judged and checked, and how to reach us
- [Pricing](https://agingresearch.news/pricing): Plus, a feed for a reader's own work, as precise as "gene therapy for mitochondria", with a match score on the papers that fit it
- [News](https://agingresearch.news/news): company, regulator and press news on aging and longevity, grouped by event
- [Trials](https://agingresearch.news/trials): new and updated clinical trials of aging and age-related conditions
- [Updates](https://agingresearch.news/updates): what readers can now do on the site, dated
- [Data API](https://agingresearch.news/developers): JSON access to papers, stories, entities, claims, trials and news, and an MCP server for AI agents at https://agingresearch.news/api/mcp
- [Use AgingResearch.News in your AI assistant](https://agingresearch.news/connect): how to add AgingResearch.News to ChatGPT, Claude, Gemini, Copilot, Grok, Perplexity, Le Chat, Muse, Cursor and Codex
- [AgingResearch.News in ChatGPT](https://agingresearch.news/connect/chatgpt): Ask ChatGPT about aging research and it answers from AgingResearch.News: new papers explained, the evidence on a drug, gene or process, clinical trials and news, each linked to its source.
- [AgingResearch.News in Claude](https://agingresearch.news/connect/claude): Add AgingResearch.News to Claude as a connector and ask about aging research: new papers explained, the evidence on a drug, gene or process, clinical trials and news, each linked to its source.
- [AgingResearch.News for Chrome](https://agingresearch.news/connect/chrome): The AgingResearch.News extension for Chrome shows a paper’s study details and related aging research beside it on PubMed or a journal’s site, and answers questions with the paper attached.
- [SKILL.md](https://agingresearch.news/skill.md): how an AI agent connects to AgingResearch.News over MCP or the data API, its tools and arguments, the limits and good first questions

## Topics

- [Mechanisms](https://agingresearch.news/topics/mechanisms): How and why aging and age-related decline happen, in any species. RSS: https://agingresearch.news/topics/mechanisms/feed.xml
- [Interventions](https://agingresearch.news/topics/interventions): Drugs, supplements, diets, exercise, devices, gene and cell therapies, reprogramming and regeneration, and what they do. RSS: https://agingresearch.news/topics/interventions/feed.xml
- [Biomarkers](https://agingresearch.news/topics/biomarkers): Aging clocks, organ age, frailty and function, risk scores and early detection. RSS: https://agingresearch.news/topics/biomarkers/feed.xml
- [Populations](https://agingresearch.news/topics/populations): Who ages how: trajectories, exposures, behaviors, healthspan and mortality in people. RSS: https://agingresearch.news/topics/populations/feed.xml
- [AI & data](https://agingresearch.news/topics/ai-data): Models, agents, datasets, atlases, benchmarks and software for aging research and longevity medicine. RSS: https://agingresearch.news/topics/ai-data/feed.xml
- [Industry & policy](https://agingresearch.news/topics/industry-policy): Companies, money, products, approvals, guidelines, laws and meetings. RSS: https://agingresearch.news/topics/industry-policy/feed.xml

## Evidence

- [Interventions](https://agingresearch.news/intervention): drugs, supplements, diets and other interventions, each with what the papers found
- [Processes](https://agingresearch.news/pathway): biological processes, such as autophagy, mTOR signaling and cellular senescence
- [Genes](https://agingresearch.news/gene): genes studied in aging research
- [Diseases](https://agingresearch.news/disease): age-related diseases
- [Biomarkers](https://agingresearch.news/biomarker): aging clocks and other measures of aging
- [Body systems](https://agingresearch.news/system): body systems, from the brain and nerves to the immune system
- [Cell components](https://agingresearch.news/component): parts of the cell, such as the mitochondrion, the lysosome and the telomere
- [Methods](https://agingresearch.news/method): research methods, from machine learning to single-cell omics
- [Organisms](https://agingresearch.news/organism): the species the work was done in
- [Hallmarks of aging](https://agingresearch.news/hallmark): the twelve hallmarks of aging, each with the papers whose processes reach it

## Latest stories

- [Chemical exposure induced an aging state in animal nerve cells](https://agingresearch.news/p/DOI-10.1016_J.JHAZMAT.2026.144095/chemical-exposure-induced-an-aging-state-in-animal-nerve-cells): Deleting a gene reduced this response in animal experiments examining how an emerging environmental chemical affected nerve cells. (Journal of Hazardous Materials · Nov 1, 2026 · Animals · Peer-reviewed)
- [Compound extends lifespan in mice with premature aging](https://agingresearch.news/p/DOI-10.1038_S41467-026-79165-6/compound-extends-lifespan-in-mice-with-premature-aging): In an animal experiment, a compound that activated a DNA repair protein eased aging-related features in mice with a premature-aging disorder. (Nature Communications · Nov 1, 2026 · Animals · Peer-reviewed)
- [Blood protein frailty score aided heart failure risk prediction](https://agingresearch.news/p/DOI-10.1016_J.IJCHA.2026.102035/blood-protein-frailty-score-aided-heart-failure-risk-prediction): In UK Biobank, a measure of how well scores distinguished five-year heart failure risk was 0.756 for blood proteins versus 0.595 for clinical frailty. (International Journal of Cardiology Heart & Vasculature · Nov 1, 2026 · Humans · Peer-reviewed)
- [Food deserts linked to higher death rates in UK Biobank](https://agingresearch.news/p/DOI-10.1016_J.SOCSCIMED.2026.119991/food-deserts-linked-to-higher-death-rates-in-uk-biobank): For each standard-deviation increase in area food-desert scores, the death-rate ratio was 1.06 after initial adjustments; the association weakened with fuller adjustment. (Social Science & Medicine · Nov 1, 2026 · Humans · Peer-reviewed)
- [Perceived stress was not linked to shingles risk overall](https://agingresearch.news/p/DOI-10.1016_J.BBIH.2026.101394/perceived-stress-was-not-linked-to-shingles-risk-overall): Among 99,686 participants, comparing the highest and lowest stress quarters gave a hazard ratio—a measure of relative risk over time—of 1.00. (Brain, Behavior, & Immunity - Health · Nov 1, 2026 · Humans · Peer-reviewed)
- [Combined lifestyle program was feasible in a small trial](https://agingresearch.news/p/MED-42966490/combined-lifestyle-program-was-feasible-in-a-small-trial): Retention was 100% in both groups in an eight-week randomized trial of 30 people with mild cognitive impairment. (Neuroscience · Nov 1, 2026 · Human trial · Peer-reviewed)
- [Spice extract reduced body fat in Korean adults with overweight](https://agingresearch.news/p/MED-42966431/spice-extract-reduced-body-fat-in-korean-adults-with-overweight): Body fat fell by 4.2 percentage points with the extract versus 0.8 with placebo in a 12-week randomized trial. (The Journal of Nutritional Biochemistry · Nov 1, 2026 · Human trial · Peer-reviewed)
- [Eye diseases linked to cognitive impairment in older adults](https://agingresearch.news/p/MED-42966472/eye-diseases-linked-to-cognitive-impairment-in-older-adults): Cognitive impairment affected 54% with diabetic retinopathy, 52% with glaucoma and 49% with age-related macular degeneration, versus 27% of controls over 10 years. (Archivos de la Sociedad Espanola de Oftalmologia · Nov 1, 2026 · Humans · Peer-reviewed)
- [Digital ease and skills had opposite links to cognitive health](https://agingresearch.news/p/MED-42966204/digital-ease-and-skills-had-opposite-links-to-cognitive-health): Across 19,521 person-year observations, perceived ease using digital technology was linked to better cognitive health, while device proficiency was linked to poorer cognitive health. (Geriatric Nursing · Nov 1, 2026 · Humans · Peer-reviewed)
- [Heart tracing pattern not independently linked to heart risk](https://agingresearch.news/p/MED-42966028/heart-tracing-pattern-not-independently-linked-to-heart-risk): Only 52% of participants with the pattern initially still had it 10 years later, and it was not independently linked to cardiovascular outcomes. (Journal of Electrocardiology · Nov 1, 2026 · Humans · Peer-reviewed)
- [Cepharanthine clears senescent cells in naturally aged mice](https://agingresearch.news/p/MED-42966158/cepharanthine-clears-senescent-cells-in-naturally-aged-mice): Experiments in naturally aged mice found that the compound also improved organ function and prolonged lifespan. (Phytomedicine · Nov 1, 2026 · Animals · Peer-reviewed)
- [Ultrasound AI identified early heart failure in adults](https://agingresearch.news/p/MED-42965535/ultrasound-ai-identified-early-heart-failure-in-adults): For distinguishing early disease, the AI scored 0.77 versus 0.70 for a clinical score in 2,544 adults without diagnosed heart failure. (JACC Heart Failure · Nov 1, 2026 · Humans · Peer-reviewed)
- [Exercise-linked protein promotes heart regeneration in mice](https://agingresearch.news/p/MED-42965864/exercise-linked-protein-promotes-heart-regeneration-in-mice): Experiments in adult mice found that giving clusterin, a protein increased by exercise, promoted heart regeneration after a heart attack. (Cell Reports · Nov 1, 2026 · Animals · Peer-reviewed)
- [An enzyme inhibitor extended lifespan in aged mice](https://agingresearch.news/p/MED-42964811/an-enzyme-inhibitor-extended-lifespan-in-aged-mice): In an experiment in naturally aged C57BL/6 mice, long-term treatment also reduced frailty and improved physical and cognitive performance. (iScience · Nov 1, 2026 · Animals · Peer-reviewed)
- [Tardigrade stress proteins shortened lifespan in worms](https://agingresearch.news/p/BIORXIV-2026.10.26.762026/tardigrade-stress-proteins-shortened-lifespan-in-worms): Experiments in genetically engineered worms found that each of four proteins impaired movement and reproduction and failed to improve resistance to most environmental stresses. (bioRxiv · Nov 1, 2026 · Model organisms · Preprint)
- [A persistent virus benefited flies under temperature stress](https://agingresearch.news/p/BIORXIV-2026.10.31.763142/a-persistent-virus-benefited-flies-under-temperature-stress): Experiments in fruit flies found that persistent Nora virus infection extended lifespan and improved reproductive output and behavioral performance under ongoing temperature stress. (bioRxiv · Nov 1, 2026 · Model organisms · Preprint)
- [Asparagus stem extract may improve memory in healthy adults](https://agingresearch.news/p/DOI-10.3177_JNSV.72.415/asparagus-stem-extract-may-improve-memory-in-healthy-adults): Memory scores improved 9.0 points more with the extract than with placebo after 12 weeks in a randomized trial. (Journal of Nutritional Science and Vitaminology · Nov 1, 2026 · Human trial · Peer-reviewed)
- [Higher remnant cholesterol linked to greater heart failure risk](https://agingresearch.news/p/DOI-10.1016_J.ATHEROSCLEROSIS.2026.121947/higher-remnant-cholesterol-linked-to-greater-heart-failure-risk): Without statins, the highest versus lowest remnant cholesterol categories had heart failure hazard ratios—relative risk measures—of 1.40 in Denmark and 1.61 in the UK. (Atherosclerosis · Nov 1, 2026 · Humans · Peer-reviewed)
- [IcoSema analysis suggests no effect on hospitalization](https://agingresearch.news/p/DOI-10.1007_S44357-026-00025-3/icosema-analysis-suggests-no-effect-on-hospitalization): Hospitalization occurred in 106 of 1,325 IcoSema recipients and 92 of 1,312 comparator recipients; median stays were 4.0 and 5.0 days, respectively. (Metabologia · Nov 1, 2026 · Human trial · Peer-reviewed)
- [Ivacaftor reduced experimental lung scarring in mice](https://agingresearch.news/p/DOI-10.1038_S41420-026-03372-9/ivacaftor-reduced-experimental-lung-scarring-in-mice): In mice with chemically induced lung scarring, the drug reduced collagen buildup and restored normal lung structure and function. (Cell Death Discovery · Oct 31, 2026 · Animals · Peer-reviewed)

## Feeds and indexes

- [Full text of recent stories](https://agingresearch.news/llms-full.txt): every story from the last seven days in Markdown, with its source paper
- [RSS, all stories](https://agingresearch.news/feed.xml)
- [Sitemap](https://agingresearch.news/sitemap.xml): the index of the site's sitemaps: stories by month, site and topic pages, evidence pages, authors, trials, organizations and people
- [Google News sitemap](https://agingresearch.news/news-sitemap.xml): stories from the last 48 hours